┌──[manu] @ [manu-PC] ─ [~]
└─➤ cat /proc/acpi/wakeup
Device	S-state	  Status   Sysfs node
GPP0	  S4	*disabled
X161	  S4	*disabled
GPP1	  S4	*disabled
GPP2	  S4	*disabled
GPP4	  S4	*disabled
GPP5	  S4	*disabled
X162	  S4	*disabled
GP17	  S4	*enabled   pci:0000:00:08.1
XHC0	  S4	*enabled   pci:0000:09:00.3
XHC1	  S4	*enabled   pci:0000:09:00.4
GP18	  S4	*enabled   pci:0000:00:08.2
PS2K	  S3	*disabled
PS2M	  S3	*disabled
UAR1	  S4	*disabled  pnp:00:04
I211	  S4	*enabled   pci:0000:03:00.0
WIBT	  S4	*disabled
PX16	  S4	*disabled  pci:0000:05:00.0
X1_1	  S4	*disabled
X1_2	  S4	*disabled  pci:0000:07:00.0
X1_3	  S4	*disabled
PTXH	  S4	*enabled   pci:0000:01:00.0
┌──[manu] @ [manu-PC] ─ [~]
└─➤ sudo udevadm control --reload-rules && sudo udevadm trigger
┌──[manu] @ [manu-PC] ─ [~]
└─➤ sudo sh -c "echo XHC0 > /proc/acpi/wakeup"
    sudo sh -c "echo XHC1 > /proc/acpi/wakeup"
    sudo sh -c "echo PTXH > /proc/acpi/wakeup"
┌──[manu] @ [manu-PC] ─ [~]
└─➤ cat /proc/acpi/wakeup
Device	S-state	  Status   Sysfs node
GPP0	  S4	*disabled
X161	  S4	*disabled
GPP1	  S4	*disabled
GPP2	  S4	*disabled
GPP4	  S4	*disabled
GPP5	  S4	*disabled
X162	  S4	*disabled
GP17	  S4	*enabled   pci:0000:00:08.1
XHC0	  S4	*disabled  pci:0000:09:00.3
XHC1	  S4	*disabled  pci:0000:09:00.4
GP18	  S4	*enabled   pci:0000:00:08.2
PS2K	  S3	*disabled
PS2M	  S3	*disabled
UAR1	  S4	*disabled  pnp:00:04
I211	  S4	*enabled   pci:0000:03:00.0
WIBT	  S4	*disabled
PX16	  S4	*disabled  pci:0000:05:00.0
X1_1	  S4	*disabled
X1_2	  S4	*disabled  pci:0000:07:00.0
X1_3	  S4	*disabled
PTXH	  S4	*disabled  pci:0000:01:00.0
┌──[manu] @ [manu-PC] ─ [~]
└─➤ 
 

script disable-usb-wakeup.sh:

#!/bin/bash
for device in XHC0 XHC1 PTXH; do
    if grep -q "$device.*enabled" /proc/acpi/wakeup; then
        echo $device > /proc/acpi/wakeup
    fi
done

/etc/systemd/system/disable-usb-wakeup.service:

[Unit]
Description=Desactivar reactivacion por USB ACPI
 
[Service]
Type=oneshot
ExecStart=/ruta/al/script/disable-usb-wakeup.sh
RemainAfterExit=yes
 
[Install]
WantedBy=multi-user.target

luego

sudo systemctl enable disable-usb-wakeup.service